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Mice pretreated with 0.5 mg/kg ALP showed preference for the environment paired with low dose of MOR (2.5 mg/kg) when compared to SAL-treated controls 1 month after cessation of pretreatment, suggesting that repeated ALP induces changes that last into adulthood

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Many ocular manifestations of glaucoma (IOP changes, calcium overloads, reactive gliosis, cytokine release, microvascular dysfunction, actin upregulation, fibronectin secretion and RGC apoptosis) can be mimicked pharmacologically by stimulating TRPV4 channels in RGCs, glial, endothelial, ciliary body and trabecular meshwork cells (27, 111, 127, 133)

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